Moffitt Cancer Center researcher helps develop prostate cancer testing, treatment guidelines

Public release date: 29-Sep-2012
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Contact: Kim Polacek
kim.polacek@moffitt.org
813-745-7408
H. Lee Moffitt Cancer Center & Research Institute

Prostate Cancer Awareness Month brings changes in treatment; controversy remains regarding diagnostic screenings

Julio M. Pow-Sang, M.D., chair of Moffitt Cancer Center's Department of Genitourinary Oncology, and colleagues have published two prostate cancer articles in the September issue of JNCCN The Journal of the National Comprehensive Cancer Network. The articles review and clarify recent updates made to the National Comprehensive Cancer Network's (NCCN) guidelines for the screening and treatment of prostate cancer.

According to the NCCN, nearly 242,000 cases of prostate cancer will be diagnosed in 2012, accounting for 29 percent of new cancers among men. It is estimated that more than 28,000 men will die from the disease this year.

According to the journal, prostate cancer is "over diagnosed and over treated" and is subject to a controversy "fueled by large screening studies." This month, Prostate Cancer Awareness Month, the NCCN has offered support for active surveillance, a strategy by which men with low-risk tumors, often classified as clinically insignificant, are monitored over time.

"Depending on the disease characteristics and the patient's life expectancy and personal preference, active surveillance may be a viable alternative to immediate and radical treatment," Pow-Sang said. "For others with high-risk, localized tumors or locally advanced disease, there are recent treatment advances that should be considered."

New agents and therapy combinations

According to the NCCN, external beam radiation and androgen deprivation therapy have been the traditional treatments for patients with high-risk tumors. However, the NCCN reports that brachytherapy, either permanent seed implant or temporary placement (high dose radiation), combined with external beam radiation and androgen deprivation therapy is increasingly being used for these patients.

The first article, Prostate Cancer, version 3.2012, noted that two new agents abiraterone acetate and immunotherapy sipuleucel-T are welcome therapeutic additions for patients with late-stage disease and poor prognosis.

Abiraterone acetate, which inhibits a key enzyme related to prostate cancer, can be given to patients after their chemotherapy. Studies have shown that it can also be used in chemotherapy-nave patients.

Sipuleucel-T, a second line therapy, is a live cancer vaccine approved in 2010 for treating asymptomatic or minimally symptomatic patients with metastatic prostate cancer. The NCCN has recommended the new drug for use after chemotherapy failure or as treatment along with chemotherapy.

"The new NCCN guidelines highlight important updates to the management of prostate cancer," concluded Pow-Sang and his co-authors. "These protocols are updated annually and more often when new, high-quality clinical data become available. The guidelines are based on evidence from clinical trials combined with expert consensus."

Active surveillance and PSA density, percent free, and biopsy cores

In a second article, Enrollment Criteria Controversies for Active Surveillance and Triggers for Conversion to Treatment in Prostate Cancer, Pow-Sang and co-author David D. Buethe, M.D., a urologic oncology fellow at Moffitt, examine the controversy and criteria for implementing active surveillance for patients with asymptomatic prostate cancer and identify the triggers that would convert active surveillance patients to active treatment status.

The authors note that for those patients with prostate cancers at low-risk for progression, the active surveillance strategy was proposed a decade ago but is recently receiving more attention as a viable management option.

"However, critical uncertainties still surround active surveillance," Pow-Sang said. "The criteria that qualify a patient as low or very low risk are not clear, nor is the definition of disease progression."

In this article, Pow-Sang and Buethe reviewed recent literature regarding those uncertainties, examining criteria for assisting in selecting men for active surveillance, including PSA density, percent free versus percent total PSA, biopsy positive core results and "volume of involvement" data.

"A PSA density of greater than 0.08 ng/mL/g has been identified as a significant predictor of future disease progression in those with low-risk prostate cancer," reported Pow-Sang. "However, some clinicians use a level of 0.15 ng/mL/g as a threshold."

Percent-free PSA has been found to be a significant predictor of organ-confined disease, said Pow-Sang and Buethe, noting that some reports have shown a significant indirect correlation between percent-free PSA and prostate cancer volume; but as yet this parameter is "not widely accepted as a predictor of cancer extent."

They also looked at studies on positive cores from biopsies and the extent to which core results could be used to develop criteria for treatment. Reports have shown the predictive value of positive biopsy cores, but the frequency for performing prostate biopsies remains controversial for outcomes of active surveillance patients, Pow-Sang said.

"Biopsies are not without consequences," he said. "Rectal bleeding and serious infectious complications from frequent biopsies need to be considered."

Additionally, no standard protocol exists, and controversy remains, for the frequency of PSA testing and the digital rectal exam for patients who are under active surveillance.

"Current guidelines vary," Pow-Sang said. "There are recommendations that the PSA and digital rectal exam should be performed every three to six months, or the PSA every three months and the digital rectal exam every six months. The frequency of biopsies is also variable, from once a year to up to every three years."

New potential tools

Pow-Sang and Buethe also report that a new tool, the PCA3 urinary marker, may be useful. PCA3 is a urine test used to quantify copies of the known prostate cancer gene 3. A PCA3 score of 35 or greater is considered possibly malignant. The test is prostate cancer specific and unaffected by prostatitis or benign prostatic hyperplasia, both of which have confounded the results of PSA testing.

The future of active surveillance

"Most studies report that 30 percent of active surveillance-classified men will be reclassified in the short term to clinically significant cancer that may require treatment," noted Pow-Sang. "Once more, PSA velocity (how quickly the PSA score rises) or PSA doubling time (how often the score doubles) has no clear role in active surveillance."

When counseling men with early prostate cancer, all treatment options, risks and complications should be discussed, Pow-Sang confirmed.

"Active surveillance is a reasonable management strategy for low-risk and very low risk prostate cancer, but allows for continual reassessment and identification of progressive tumors."

###

About Moffitt Cancer Center

Located in Tampa, Moffitt is one of only 41 National Cancer Institute-designated Comprehensive Cancer Centers, a distinction that recognizes Moffitt's excellence in research, its contributions to clinical trials, prevention and cancer control. Since 1999, Moffitt has been listed in U.S. News & World Report as one of "America's Best Hospitals" for cancer. With more than 4,200 employees, Moffitt has an economic impact on the state of nearly $2 billion. For more information, visit MOFFITT.org, and follow the Moffitt momentum on Facebook, twitter and YouTube.

Media release by Florida Science Communications

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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Public release date: 29-Sep-2012
[ | E-mail | Share ]

Contact: Kim Polacek
kim.polacek@moffitt.org
813-745-7408
H. Lee Moffitt Cancer Center & Research Institute

Prostate Cancer Awareness Month brings changes in treatment; controversy remains regarding diagnostic screenings

Julio M. Pow-Sang, M.D., chair of Moffitt Cancer Center's Department of Genitourinary Oncology, and colleagues have published two prostate cancer articles in the September issue of JNCCN The Journal of the National Comprehensive Cancer Network. The articles review and clarify recent updates made to the National Comprehensive Cancer Network's (NCCN) guidelines for the screening and treatment of prostate cancer.

According to the NCCN, nearly 242,000 cases of prostate cancer will be diagnosed in 2012, accounting for 29 percent of new cancers among men. It is estimated that more than 28,000 men will die from the disease this year.

According to the journal, prostate cancer is "over diagnosed and over treated" and is subject to a controversy "fueled by large screening studies." This month, Prostate Cancer Awareness Month, the NCCN has offered support for active surveillance, a strategy by which men with low-risk tumors, often classified as clinically insignificant, are monitored over time.

"Depending on the disease characteristics and the patient's life expectancy and personal preference, active surveillance may be a viable alternative to immediate and radical treatment," Pow-Sang said. "For others with high-risk, localized tumors or locally advanced disease, there are recent treatment advances that should be considered."

New agents and therapy combinations

According to the NCCN, external beam radiation and androgen deprivation therapy have been the traditional treatments for patients with high-risk tumors. However, the NCCN reports that brachytherapy, either permanent seed implant or temporary placement (high dose radiation), combined with external beam radiation and androgen deprivation therapy is increasingly being used for these patients.

The first article, Prostate Cancer, version 3.2012, noted that two new agents abiraterone acetate and immunotherapy sipuleucel-T are welcome therapeutic additions for patients with late-stage disease and poor prognosis.

Abiraterone acetate, which inhibits a key enzyme related to prostate cancer, can be given to patients after their chemotherapy. Studies have shown that it can also be used in chemotherapy-nave patients.

Sipuleucel-T, a second line therapy, is a live cancer vaccine approved in 2010 for treating asymptomatic or minimally symptomatic patients with metastatic prostate cancer. The NCCN has recommended the new drug for use after chemotherapy failure or as treatment along with chemotherapy.

"The new NCCN guidelines highlight important updates to the management of prostate cancer," concluded Pow-Sang and his co-authors. "These protocols are updated annually and more often when new, high-quality clinical data become available. The guidelines are based on evidence from clinical trials combined with expert consensus."

Active surveillance and PSA density, percent free, and biopsy cores

In a second article, Enrollment Criteria Controversies for Active Surveillance and Triggers for Conversion to Treatment in Prostate Cancer, Pow-Sang and co-author David D. Buethe, M.D., a urologic oncology fellow at Moffitt, examine the controversy and criteria for implementing active surveillance for patients with asymptomatic prostate cancer and identify the triggers that would convert active surveillance patients to active treatment status.

The authors note that for those patients with prostate cancers at low-risk for progression, the active surveillance strategy was proposed a decade ago but is recently receiving more attention as a viable management option.

"However, critical uncertainties still surround active surveillance," Pow-Sang said. "The criteria that qualify a patient as low or very low risk are not clear, nor is the definition of disease progression."

In this article, Pow-Sang and Buethe reviewed recent literature regarding those uncertainties, examining criteria for assisting in selecting men for active surveillance, including PSA density, percent free versus percent total PSA, biopsy positive core results and "volume of involvement" data.

"A PSA density of greater than 0.08 ng/mL/g has been identified as a significant predictor of future disease progression in those with low-risk prostate cancer," reported Pow-Sang. "However, some clinicians use a level of 0.15 ng/mL/g as a threshold."

Percent-free PSA has been found to be a significant predictor of organ-confined disease, said Pow-Sang and Buethe, noting that some reports have shown a significant indirect correlation between percent-free PSA and prostate cancer volume; but as yet this parameter is "not widely accepted as a predictor of cancer extent."

They also looked at studies on positive cores from biopsies and the extent to which core results could be used to develop criteria for treatment. Reports have shown the predictive value of positive biopsy cores, but the frequency for performing prostate biopsies remains controversial for outcomes of active surveillance patients, Pow-Sang said.

"Biopsies are not without consequences," he said. "Rectal bleeding and serious infectious complications from frequent biopsies need to be considered."

Additionally, no standard protocol exists, and controversy remains, for the frequency of PSA testing and the digital rectal exam for patients who are under active surveillance.

"Current guidelines vary," Pow-Sang said. "There are recommendations that the PSA and digital rectal exam should be performed every three to six months, or the PSA every three months and the digital rectal exam every six months. The frequency of biopsies is also variable, from once a year to up to every three years."

New potential tools

Pow-Sang and Buethe also report that a new tool, the PCA3 urinary marker, may be useful. PCA3 is a urine test used to quantify copies of the known prostate cancer gene 3. A PCA3 score of 35 or greater is considered possibly malignant. The test is prostate cancer specific and unaffected by prostatitis or benign prostatic hyperplasia, both of which have confounded the results of PSA testing.

The future of active surveillance

"Most studies report that 30 percent of active surveillance-classified men will be reclassified in the short term to clinically significant cancer that may require treatment," noted Pow-Sang. "Once more, PSA velocity (how quickly the PSA score rises) or PSA doubling time (how often the score doubles) has no clear role in active surveillance."

When counseling men with early prostate cancer, all treatment options, risks and complications should be discussed, Pow-Sang confirmed.

"Active surveillance is a reasonable management strategy for low-risk and very low risk prostate cancer, but allows for continual reassessment and identification of progressive tumors."

###

About Moffitt Cancer Center

Located in Tampa, Moffitt is one of only 41 National Cancer Institute-designated Comprehensive Cancer Centers, a distinction that recognizes Moffitt's excellence in research, its contributions to clinical trials, prevention and cancer control. Since 1999, Moffitt has been listed in U.S. News & World Report as one of "America's Best Hospitals" for cancer. With more than 4,200 employees, Moffitt has an economic impact on the state of nearly $2 billion. For more information, visit MOFFITT.org, and follow the Moffitt momentum on Facebook, twitter and YouTube.

Media release by Florida Science Communications

---

[ | E-mail | Share ]

?

AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Source: http://www.eurekalert.org/pub_releases/2012-09/hlmc-mcc092712.php

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Eavesdropping on Jenny & Ashley 10/01 by Top 7 | Blog Talk Radio

The Movie Geeks speak with acclaimed actor Vincent D'Onofrio (Full Metal Jacket, Men in Black, Law & Order: Criminal Intent) about the highlights of his extraordinary career, and his new film Chained, which is now available on DVD and blu-ray.

Butz and Butz Sports Radio broadcast live from the bar at the One Crazy Fan Tailgate Truck at Lincoln Financial Field with former Eagles Pro Bowl linebacker William Thomas.

At only 20 years old, J. Anton Boykin is already affectionately known as the "Sax Sensation." Since the age of eight he has been mastering the craft of music. Come listen to him talk about what inspires him.

EGH Media presents Rowan Galagher who is The Mad Pride. A singer, songwriter and instrumentalist who doesn't read music and also successfully controls Tourette?s syndrome.

MGN Radio welcomes Author Ngozi Achebe to discuss her new book, Onaedo - The Blacksmith's Daughter on our show. Her debut novel has already been nominated for several literary awards.

The Gridiron Chefs with TP Tymless and James Greenwood break down the weeks games in the NFL, the pressing topics around the league and listener questions.

This week Tim and Jill will finish the discussion on LGBT and Marriage Equality, this is a hot topic that has been trending on social networks and is an important issue for voters as we near election time.

Francy and Friends will be LIVE from The Days of Terror Convention, be sure to tune in as they will be meeting some of the biggest names in horror films. You never know who you might run into.

It's open-wheel racing and NASCAR on this episode, as Dustin Parks will be joined by guest co-host Glenn Locke. These two always bring great conversation, and this will be no different.

Grab your Saturday morning coffee and tune into "Those Diner and Motorcycle Guys" hosted by those eggs over easy riders Garrison Leykam and Scot Doane. "Those Diner and Motorcycle Guys"...talk radio was never like this!

BGE Radio welcomes Playboy Model Crissy Henderson to the show. Crissy is an actress, model and philanthropist. Tune in as she speaks about her life and upcoming work.

Source: http://www.blogtalkradio.com/top-7/2012/10/02/eavesdropping-on-jenny-ashley

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Routes 2012: Thomson prepares to become first leisure Dreamliner ...

Thomson Airways will next year become the first leisure carrier to begin passenger operations with the Boeing 787 Dreamliner.?

The airline, part of the European tour operator TUI, plans to introduce the type into service from May 1st, 2013 and is currently looking at the exciting network opportunities the modern generation airliner will bring to its customers.

When Boeing launched the Dreamliner programme, its sales executives highlighted the wonderful new flight options it would bring to potential customers, but with some of the world?s leading business airlines among the first to operate the jet, it has to date mainly been used to serve key markets.

The arrival of the first aircraft with Thomson Airways late in the first quarter of 2013 will see the Dreamliner make its debut in the charter sector and will bring opportunities for the carrier?s parent to offer many new niche travel options that it previously could not operate.

To celebrate the arrival of the new aircraft, a revised aircraft interior and the brand new livery design for Thomson Airways, as well as other TUI Travel Group airlines has been launched.?

Thomson intends to configure its aircraft to carry 291 passengers.? A Premium Club cabin will seat 47 in a 2-3-2 configuration, each with a 38? pitch, and the Economy Club cabin will seat 244 in a 3-3-3 configuration, each with a 33? or 34? pitch.

Over the next three years Thomson Airways will receive eight of the 13 Dreamliners currently ordered by TUI Travel, but with 13 purchase options there is scope for further growth.

The first four are provisionally due to arrive in 2013, three more in 2014 and the last in 2015.

Recommended

Source: http://www.breakingtravelnews.com/news/article/routes-2012-thomson-prepares-to-become-first-leisure-dreamliner-operator/

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Georgia Southern University Students Vote to Support Three Proposed Student Fees

A record number of Georgia Southern University students cast their ballots to support three new proposed student fees during an online vote this past week.?

A record turnout of more than 9,390 students, nearly 55 percent of eligible students (students who paid Student Activity Fees this semester), voted to approve three fees including: a fee to fund an expansion of Allen E. Paulson Football stadium ($25); a fee to fund Georgia Southern's potential move up to the Football Bowl Subdivision ($75); and a fee support for Sustainability and Green efforts on campus ($10).?

?The University will now forward the proposed fees to the University System of Georgia?s Board of Regents for their review and consideration.?

?This past week a record number of Georgia Southern students voted on three proposed student fees and to express their support for the future direction of this great University,? said Dominique Quarles, president of the Student Government Association at Georgia Southern.? ?The University asked us for our opinion and the results speak for themselves.?

??This has been a student-led process from the beginning, and we are exceptionally proud of the effort our Student Government Association has made to provide objective information and encourage their fellow students to vote.? This entire process is another example of the student-centeredness of Georgia Southern,? said Georgia Southern University President Brooks Keel, Ph.D.? ?Whether it in the area of academics, research, sustainability, economic development or athletics, our goal is to take Georgia Southern University to the next level,? said Keel.? ?From what I have been told, this is one the largest turnouts for a student vote on our campus.?

?While there has been much discussion about the two athletic-related fees, Georgia Southern University leaders were particularly impressed with the high vote of confidence that the sustainability efforts fee received.? The proposed $10 fee passed with 7,018 students (74.9%) voting in favor.? This past year, Georgia Southern was nationally recognized for its efforts when it was named to the Princeton Review's Guide to 322 Green Colleges, recognizing the University's commitment to sustainability and green initiatives.

?Georgia Southern students have a desire to make a difference in the world.? They want to improve their surroundings and are very aware and interested in topics concerning the environment,? said Keel.?

?Next Step

?The student vote is just the first step in the process.? The University will now forward the proposed fees to the University System of Georgia?s Board of Regents for their review and consideration.? If approved, the expansion fee and sustainability fee will go into effect Fall 2013.? If approved, the ?FBS fee? will not go into effect until Georgia Southern University is offered and accepts an invitation to join an FBS conference.? Timing for implementing the ?FBS fee? will be dependent upon when the University receives an invitation from an FBS conference.

By the Numbers: Student Fee Vote Results

?Expansion of Allen E. Paulson Football Stadium Fee ($25)

• Total Voters: ?9,390
  • Yes: 6,612 (70.4% of the vote)?
  • No: 2,778 (29.6% of the vote)

Fee to Fund Potential Move Up to the Football Bowl Subdivision Fee ($75)

• Total Voters:? 9,390
  • Yes: 5,748? (61.2% of the vote)
  • No: 3,642 (38.8% of the vote)

?Sustainability Efforts Fee ($10)

• Total Voters:? 9,390
  • Yes: 7,018 (74.7% of the vote)
  • No: 2,372 (25.3% of the vote)?

About the Fees:

?Expansion of Allen E. Paulson Football Stadium Fee ($25)

This fee will support a $25 fee to increase the seating capacity of Allen E. Paulson Stadium by more than 6,300 seats. The new addition will add an upper deck to the student/visitor side of the stadium. Currently, the stadium has 4,000 seats dedicated for student use. With more than 20,000 students attending Georgia Southern again this fall, only 25 percent of the University?s student body was able to be provided with a seat during home football games. By increasing the capacity of the stadium now, Georgia Southern will be well positioned for a future move to the Football Bowl Subdivision or FBS. The new seats, which this fee will fund, will be dedicated for student use each home football game.

?In addition to football games, the expansion will also provide additional seating for graduation ceremonies and special events. The stadium currently seats a total of 14,444 people. Each spring, the stadium is filled to capacity and beyond with more than 23,000 family members and friends attending its annual undergraduate commencement ceremony. In addition, the University hosts a variety of other events at the stadium including last spring's concert of The Band Perry and The Fray.?

?Note: Once the total cost of construction has been fully paid, this fee will no longer be assessed to students.

?Fee to Fund Potential Move Up to the Football Bowl Subdivision Fee ($75)

This fee will fund a University FBS Athletic Operations Fee. Georgia Southern recently expressed interest in moving up to compete with other major universities in the Football Bowl Subdivision series. This $75 fee will support Georgia Southern Football's move to a new level of competition as well as a move to a new athletic conference. In order to make a move to the FBS, two things must happen. First, the funding for such a move must be in place and second, the University must be invited to join a new conference.

Georgia Southern Athletics strives to compete and succeed at the highest possible level and gain national recognition for our teams, student-athletes, coaches, and Georgia Southern University. The University?s student athletes maintain integrity and sportsmanship and work hard to exceed the NCAA academic standards and Georgia Southern graduation rates. This fee will allow for the addition of new student-athlete scholarships to meet the minimum football requirements for the FBS classification, for women's athletics and the addition of another women's sport which would be required.

?Because the state of Georgia does not fund athletic department operations, this fee will ensure that the University has the necessary funding to make a move up when a conference invitation is presented. There are no plans to charge students for individual game tickets during regular season play and the FBS fee will only be assessed if Georgia Southern is invited to join a new conference at the higher level of competition.

?Sustainability Efforts Fee ($10)

This $10 fee will support Sustainability and Green initiatives on campus. For the second straight year Georgia Southern was named to the Princeton Review's Guide to 322 Green Colleges, recognizing the University's commitment to sustainability and green initiatives.

The Sustainability fee will go toward sustainable projects on campus such as retro-fitting buildings, low-flow shower heads, re-lamping, etc., to make the University more water and energy efficient. It will also aid in promotional efforts to encourage a green lifestyle across campus.? Additionally, the fee will go toward environmental education, bringing in influential outside guest speakers like Majora Carter and Ed Begley, Jr., who have spoken in the past at Georgia Southern. The fee will also aid in hiring personnel for the Center for Sustainability.

Georgia Southern University, a Carnegie Doctoral/Research University founded in 1906, offers more than 120 degree programs serving more than 20,000 students. Through eight colleges, the University offers bachelor?s, master?s and doctoral degree programs built on more than a century of academic achievement.? In 2012, the University was named one of the Top 10 most popular universities in the country by?U.S. News & World Report?and is a top choice of Georgia?s HOPE scholars.? Georgia Southern is recognized for its student-centered approach to education. Visit:?www.georgiasouthern.edu.

Source: http://news.georgiasouthern.edu/viewArticle.php?id=2308

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Merrithew Health & Fitness Returns to MEDICA with New Fitness ...

MERRITHEW HEALTH & FITNESS RETURNS TO MEDICA WITH NEW FITNESS BRAND TO COMPLEMENT MINDFUL MOVEMENT

Control breathing, stability and the mind-body connection
Toronto, Ontario, Aug. 15, 2012 ? Merrithew Health & Fitness? makes its second appearance at MEDICA, the world?s largest annual medical trade show, November 14-17 in D?sseldorf, Germany, featuring ZEN?GA?, one of it?s newest fitness brands. ZEN?GA provides a unique blend of the foundational principles of STOTT PILATES?, yoga and dance to create an innovative fusion workout, bringing more mindful movement to every move.

?Our goal is to continuously provide superior products, services and equipment lines for professional and consumer use,? explains Lindsay G. Merrithew, President and CEO, Merrithew Health & Fitness. ?ZEN?GA will truly add diversity and complement current rehabilitative program offerings. Professionals and consumers alike will benefit from the experience of our trainers, researchers, and staff who have been in the health and fitness industry for over 20 years.?

ZEN?GA provides clients and rehab patients with more opportunity to leverage various programming in the mainstream fitness and personal training industry. It is another training modality for a healthcare professional to add to their repertoire of skills and offerings or recommend to their patients.

Based on STOTT PILATES foundational principles, ZEN?GA movements engage every muscle, heighten body awareness, and enhance the mind-body connection that are vital to any rehab program.

?When these modalities are combined, your focus will be on clarity of the mind, core stability, stamina, and resilience. With that, we are able to incorporate various pieces of equipment and accessories into the many ZEN?GA programs including the use of the Mini Stability Ball? set,? says PJ O?Clair, Master Instructor Trainer, Merrithew Health & Fitness. ?ZEN?GA increases your awareness to the deep stabilizing muscles of the body through practical restorative exercises. Combining balance, strength and fluid mindful movement, this routine brings a sense of composure to any rehabilitative, group or personal training environment.?

Merrithew Health & Fitness is committed to developing high-integrity fitness programs, products and services across a variety of disciplines that help people of all ages and abilities achieve a healthy lifestyle through their premium brands STOTT PILATES, ZEN?GA and CORE Athletic Conditioning & Performance Training. Merrithew?s Media Division (MMD) produces high-quality print and video based content for professional and consumer markets.

Distributors, fitness professionals, physiotherapists, and all other health and fitness related professionals are invited to visit us at MEDICA, booth H40, Hall 4 in the Canadian Pavilion and experience what ZEN?GA can do for your clients.

In the meantime, for more information, please contact:

communications@merrithew.com

Exhibitor Data Sheet

Source: http://biomedme.com/general/merrithew-health-fitness-returns-to-medica-with-new-fitness_40436.html

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RIM posts big loss but not as bad as expected

FILE - In a Thursday June 21, 2012 file photo, Tim Neil, Research In Motion Ltd.'s Canadian Operating Director of Operations, Platforms and Tools, speaks about the Blackberry 10 architecture during the RIM Blackberry 10 Jam World Tour in Toronto. Struggling BlackBerry-maker Research in Motion said Friday, Sept. 21, 2012 it resolved an outage affecting users in Europe, Middle East and Africa that had interrupted service for customers on the very day Apple Inc. unveiled its new iPhone 5. Jefferies analyst Peter Misek said he thinks the transition to the BlackBerry 10 software intended to run their new line of smartphones, could be a cause of the outage. (AP Photo/The Canadian Press, Aaron Vincent Elkaim, File)

FILE - In a Thursday June 21, 2012 file photo, Tim Neil, Research In Motion Ltd.'s Canadian Operating Director of Operations, Platforms and Tools, speaks about the Blackberry 10 architecture during the RIM Blackberry 10 Jam World Tour in Toronto. Struggling BlackBerry-maker Research in Motion said Friday, Sept. 21, 2012 it resolved an outage affecting users in Europe, Middle East and Africa that had interrupted service for customers on the very day Apple Inc. unveiled its new iPhone 5. Jefferies analyst Peter Misek said he thinks the transition to the BlackBerry 10 software intended to run their new line of smartphones, could be a cause of the outage. (AP Photo/The Canadian Press, Aaron Vincent Elkaim, File)

FILE-In this Tuesday, Sept. 25, 2012, file photo, Thorsten Heins, President and CEO of Research in Motion, speaks during a demonstration of the new BlackBerry 10 at the BlackBerry Jam Americas conference in San Jose, Calif. BlackBerry-maker Research In Motion posted another large loss in the second quarter but not as bad as analysts expected. Shares surged nearly 18 percent in after-hours trading. The Canadian company reported Thursday, Sept. 27, 2012, that it lost $235 million, or 45 cents a share, in its fiscal second quarter, which ended Sept 1. That compares with a profit of $419 million, or 80 cents per share, a year ago. (AP Photo/Eric Risberg, File)

TORONTO (AP) ? BlackBerry-maker Research In Motion posted another large quarterly loss on Thursday, but the hemorrhaging was not as bad expected.

The Canadian company is still losing market share in North America, where it struggles to compete with Apple's iPhone and phones that run Google's Android software. But it has stepped up sales in developing markets and actually increased its subscriber base and cash position.

RIM's stock surged more than 20 percent in after-market trading on the news.

The company reported Thursday that it lost $235 million, or 45 cents a share, in its fiscal second quarter, which ended Sept 1. That compares with a profit of $419 million, or 80 cents per share, a year ago.

RIM reported revenue of $2.9 billion.

Analysts polled by FactSet expected a loss of 47 cents on revenue of $2.49 billion.

RIM said it shipped 7.4 million BlackBerry smartphones in the quarter, down from 10.6 million in the same period last year. Some analysts predicted RIM would ship only 6.4 million devices as the company prepares to launch much-delayed new BlackBerrys that have been deemed critical to its survival.

RIM pioneered the smartphone in 1999 but North American consumers have been abandoning BlackBerrys for flashier, touchscreen phones in recent years. RIM is banking its future on its much-delayed BlackBerry 10 platform, which is meant to offer the multimedia, Internet browsing and apps experience that users now demand.

Chief Executive Thorsten Heins said on a conference call with analysts that BlackBerry 10 is still on track to be released in the first quarter of 2013 ? several months after the release of Apple's iPhone 5, which came out earlier this month. Heins said competitors have released strong products recently but vowed BlackBerry 10 "will advance the operating system environment to a whole new level."

Heins replaced co-CEOs Jim Balsillie and Mike Lazaridis in January after the company lost tens of billions in market value. He surprised many this week when he said at a conference for mobile applications developers that RIM has 80 million subscribers, up from 78 million in early June. Many analysts had expected RIM to start losing subscribers in the second quarter.

The results show that RIM is making progress as it transitions to its next generation of BlackBerry smartphones and completes its cost reduction plan, Heins said.

Jefferies analyst Peter Misek said RIM did a great job in the quarter, considering the challenges it faced. He noted, however, that doesn't account for much because its new smartphones are not out yet.

"They are driving sales in emerging markets and we think they will continue to lose subscribers in developed markets," Misek said. "It doesn't tell you anything about the long-term success of the platform or the company."

RIM's sales outside the United States, United Kingdom and Canada were about 58 percent of total revenue, said Brian Bidulka, the company's chief financial officer. He noted sales were strong in Indonesia, South Africa and Venezuela, but declined in the U.S.

Sales in the U.S. represented 22 percent of revenue, down from 25 percent in the first quarter and 27 percent in the second quarter last year. Bidulka said RIM's business will continue to be challenged until the new BlackBerrys are launched.

Research firm IDC says BlackBerry's U.S. market share has plummeted from 45.8 percent in 2008 to 2.7 percent in 2012.

RIM has been laying off thousands of workers to offset the losses.

Heins noted RIM's cash position stood at $2.3 billion at Sept. 1, up from $2.2 billion at the end of the previous quarter. The company is very focused on maintaining a strong financial position as it transitions to the new platform, he said.

Colin Gillis, an analyst with BGC Financial, said RIM's ability to grow the subscriber base while not hurting its cash position is encouraging.

"It does give them more time. The talk of bankruptcy has probably dissipated right now," Gillis said. "These are all the right moves, but does it change that their position is still bleak?"

RIM's stock rose $1.46 cents to $8.60 in extended U.S. trading Thursday. It had ended the regular trading session up 14 cents at $7.14. RIM's struggles have wiped out some $80 billion in shareholder wealth since 2008, a drop of over 90 percent.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/f70471f764144b2fab526d39972d37b3/Article_2012-09-27-Earns-Research%20In%20Motion/id-afda6d93d4a7485e997f60c033201bb0

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Need To Know ? Commercial Real Estate | Key West Commercial ...

People are attracted to commercial real estate investing for a number of reasons. However, you need to decide whether an investment is right for you. The more knowledgeable you are about commercial real estate, the more lucrative it can be. The tips in the article below will help you add to your real estate knowledge.

When you?re writing letters of intent, try to keep it brief by agreeing with the bigger issues initially and let the lesser issues be resolved at a later time. This will diffuse tension during negotiations and will facilitate compromise on the minor issues.

Do a walk-through of each property on your short list. It may be a good idea to take a professional contractor with you when you check out properties you are interested in purchasing. Begin negotiating and the process of offers and counter offers. Carefully look over any counteroffers you receive before you make your final choice, whatever that may be.

TIP! Plan on doing some improvements to your new commercial space before you can inhabit it. It could be something simple, such as paining walls, rearranging appliances or furniture or hanging things.

Make sure you know what your needs are before you start looking at commercial real estate. You should know precisely what your business?s office space requirements are. If you?re interested in eventually expanding your business, buy more office space than you currently need. This saves money in the long run because prices may be higher by the time you?re ready for more office space.

The neighborhood where the property is located is very important. If you buy property in a very affluent area, your business will likely be successful, because your clientele will be better able to afford what you are selling. You might want to buy a property in a less affluent neighborhood if you are selling products or services that less affluent people would find attractive.

TIP! Seek the council of an experienced real estate attorney to help you with your commercial purchase. If something horrible happens when you are dealing with real estate, the right attorney can make a world of difference.

If you are investing in real estate, consider going big. If you believe that you can easily manage five units, you can probably easily manage 50. That many units still need commercial financing like the larger ones do, and the larger ones generally cost less for every unit.

Never underestimate the help that your relationships with private lenders and investors can lend you when dealing in commercial real estate. For example, commercial properties are often sold without ever making it to a listing, so having a broad network can increase your exposure to great deals.

Buy apartment complexes with large numbers of units. You can spread your wealth that is obtained by each one, by having more units. Properties with fewer than ten units are often harder to sell, since many investors believe that more units mean more money.

TIP! It is necessary that you have financial statements for yourself and for your business handy if you want to finance a commercial real estate property. Without financial statements, a bank cannot verify your income and will not allow you to borrow money.

There are a myriad of reasons to expand your monetary investments into commercial real estate. All it takes is determination, and a good base of information. Use the information you learned in this article to fit your plans for commercial real estate. When you do this, profit and success will be

For more information about Key West Commercial Real Estate contact Gary Smith at http://www.keywestlifestyle.com/commercial.html

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Source: http://www.keywestlifestyle.com/blog/key-west-commercial-real-estate/need-to-know-commercial-real-estate/

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National Prostate Cancer Awareness Month

This is Prostate Cancer Awareness Month and if you are 50 year old or older or if you have a history of prostate cancer in your family doctors say you need prostate cancer test. Jim Miller of Yakima says it could save your life. Miller is a prostate cancer survivor who tells KIT News, he was lucky because he found his cancer early because he saw his doctor at the right time.

Unfortunately the disease kills 30 thousand men each year and your risk for the disease is higher. Doubling, if your father, brother or close male blood relative has had the disease. Miller says the key is early detection. You can learn more at prostatehealthguide.com

Source: http://newstalkkit.com/national-prostate-cancer-awareness-month/

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IIT VP of External Affairs David Baker Elected President of the ...

IIT Vice President of External Affairs and University Technology Park Executive Director David Baker was elected president of the Association of University Research Parks (AURP) Board of Directors. AURP made the announcement on September 20 at the 2012 International Conference in Madison, Wisc.

?International relations have always been important to David Baker and he was instrumental in the success of AURP?s first international meeting which was held in Dublin, Ireland this year,? said Eileen Walker, AURP? chief executive officer. ?He understands the importance of building strong relationships with our colleagues around the world and will lead AURP in setting strategic objectives to further the association?s international reach.?

In his role at IIT, Baker is responsible for the university?s governmental relations, technology park development, and trustee relations. Over the past 11 years, Baker has worked to create the University Technology Park at IIT of which he serves as executive director. He also helped open the Perspectives/IIT Math and Science Academy, a public grade 6-12 charter school in September 2008.

As AURP President, Baker plans to enhance the association?s international presence and identify strategic objectives for the next five years.

?University research parks are driving economic growth around the world,? said Baker. ?We must partner beyond geographic borders to create knowledge, help grow companies and create high-wage jobs in our own communities.?

At the annual conference, AURP also announced newly elected Board Members: Cameron McCoy of the University Research Campus at the University of Oklahoma, Jaime Parada-Avila of Instituto de Innovaci?n y Transferencia de Tecnolog?a de Nuevo Leon and Teresa McKnight of the Montana State University Innovation Campus.

Harold Strong of the University of North Texas received an appreciation award for his service on the AURP Board of Directors and Kevin Byrne of the University Financing Foundation received the Presidential Award for his service as AURP President.

About AURP: The Association of University Research Parks is a professional association of university related research and science parks. AURP?s mission is to foster innovation, commercialization and economic growth through university, industry and government partnerships. For more information, visit AURP?s Web site at www.aurp.net or contact Chelsea Simpson at chelseasimpson@aurp.net.

Source: http://www.iit.edu/news/iittoday/?p=7811&utm_source=rss&utm_medium=rss&utm_campaign=iit-vp-of-external-affairs-david-baker-elected-president-of-the-association-of-university-research-parks

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Green ideas for green manufacturing | Eco-Business.com

The Fujisawa City project in the Kanagawa Prefecture near Tokyo brought together nine companies and the government to develop an energy-smart community. Image: Panasonic

In this interview by Singapore?s Energy Market Authority, Panasonic Asia Pacific managing director Yorihisa Shiokawa reveals how manufacturers can contribute to an energy efficient society through innovation, collaboration and careful management.

Energy Market Authority: Panasonic?s ambition is to be the leading ?Green Innovation Company? in the electronics sector. What steps is Panasonic undertaking to achieve this target? What impact will this have on consumers and the environment?

Yorihisa Shiokawa: We want to become the number one Green Innovation Company in the electronics sector by 2018. Through our ?eco ideas? strategy, we create innovative businesses, products and services that are energy-efficient or have smart energy features, and therefore are more environmentally-friendly. But they also help consumers save money. We are on track to achieving 80 per cent of our total sales in Asia Pacific from these eco products.

Panasonic Group is also focused on developing Total Energy Solutions that involve energy creation, storage, savings and management. We set up the Panasonic Energy Solutions Development Centre Singapore in July this year to develop total energy solutions not only for the region, but also to commercialise them globally. Panasonic is working closely with the local authorities in Singapore to test-bed some of our urban solutions at the?Punggol Eco-Town project.

We have a Panasonic Eco Learning Programme, which will help 200,000 students across Asia Pacific to develop environmental awareness and an understanding of how virtually zero CO2 emissions can be achieved through technology. We will continue to spread the word so that more will come together to create a positive impact on the environment.

Panasonic applies the ?eco ideas? strategy to our own business. We aim to reduce the environmental impact of our business operations by making the best use of resources and energy through green innovation. We have set a goal of a 600,000-tonne CO2 reduction in our operations versus a ?business-as-usual? level (based on our fiscal year ending March 2005).

We are also developing three more ?eco ideas? factories by March 2013, which will demonstrate our sustainability solutions and capabilities. These factories adopt green solutions and exemplify how reductions in CO2 emissions, managing waste generation and chemical substance releases and maintaining energy efficiency can be achieved in manufacturing facilities.

EMA: In difficult economic times, some consumers may not be inclined to pay for green-certified appliances. What role can global manufacturers play in raising the awareness of the importance of such appliances?

YS: Global manufacturers can take the lead to help imbue eco-consciousness among consumers though championing environmental awareness programmes and education initiatives. Industry players must work with governments worldwide to ensure their products are compliant with the energy regulations of each country. In Singapore, Panasonic?s air conditioners and refrigerators meet the standards which are required for The Energy Label, mandated by the National Environment Agency (NEA).

Asia Pacific also has many environmental challenges in emerging and rapidly growing markets. Economic growth can create environmental pressures ? especially in creating and providing a stable supply of energy and meeting the demand for improved living standards. Product customisation for particular markets is important. In India, for example, the CUBE air-conditioner takes into account specific Indian climatic conditions and space limitations. This kind of product customisation will encourage customers to purchase green-certified appliances.

EMA: Businesses, especially manufacturing companies, are some of the biggest consumers of energy. How do you think businesses can and should conserve energy through their own business practices?

YS: Business growth must be achieved with an eye on conserving the planet for future generations. We are committed to promoting environmental sustainability and reducing the impact of our business operations. There are two ways to achieve this:

First, look at reducing CO2 emission. Panasonic has been using meters and gauges to manage energy consumption during production, as well as replacing fluorescent lights with energy-efficient Light-Emitting Diode (LED) lights in our factories. By doing so, we have been able to reduce CO2 emissions by 560,000 tonnes in our Asia-Pacific operations as of the end March this year.

Second, companies should set assessment criteria on the environmental impact of their products. This needs to be done right from the planning and design stage. Improved environmental performance can be based on criteria such as energy savings, resource savings and chemicals management.

EMA: There is much being said about public-private partnerships in developing solutions that lower energy consumption. How have Japanese companies, for instance, collaborated with the Japanese government to help meet nationwide energy intensity goals?

YS: In Japan, such collaborations are increasingly important for a nation that is dependent on imports of virtually all fossil fuels. For decades, Japanese energy policy has focused on efficiency, diversity and development of indigenous energy sources.

One such recent project is Fujisawa City in Kanagawa Prefecture, situated about 50km west of Tokyo. This collaboration sees nine companies coming together with the government to build an innovative smart town deploying services and energy systems based on Panasonic?s ?eco ideas? for green lifestyles. The companies include developers, manufacturers and service providers and will see an eventual actual operation of the town with about 1,000 households. The smart town is to be built on the vacant lot of Panasonic?s former factory site and is targeted to open in the fiscal year ending in March 2014.

Apart from these large-scale collaborations, there are other ways to contribute to the nation, especially in times of crisis. At the end of March 2011, Panasonic donated a Life Innovation Container to the Miyagi Prefecture, which suffered widespread devastation in the Great East Japan Earthquake. The container is a standalone power system equipped with solar panels and rechargeable batteries to deliver electricity to areas without access to electricity.

But such collaborations are picking up in other parts of Asia as well. For example in Singapore, we are partnering with the Housing Development Board (HDB), Energy Market Authority (EMA) and Economic Development Board (EDB) to test-bed total energy solutions on an existing public residential building in Punggol Eco-Town. This project aims to achieve zero CO2 emissions for common areas of public housing in Singapore, and provide residents with a complete total energy solutions package that helps monitor and better manage their energy consumption.

EMA: Do you think companies can combine making contributions to the environment with business growth? Do you think legislation, such as those enacted in Japan and soon to be enacted in Singapore, will push companies to be more energy-efficient?

YS: Our belief is that we must integrate environmental conservation with business growth.? As such, we strive to achieve the highest achievement levels in reducing CO2 emissions, recycling resources, the size of our energy systems business and the sales ratio of environmentally-friendly products. These are our ?Green Indexes? and they are just as important as our Global Excellence Indexes, which look at sales, operating profit and return of equity.

Legislation also has a role to play in driving mindset changes in energy consumption and the nation?s energy mix.? In July 2012, the Japanese government rolled out feed-in tariffs (FiTs) for renewable energy. The Japanese FiTs are significantly higher than those offered in both Germany and China. Such clean energy investments shift Japan?s reliance on nuclear energy. Government subsidies benefit solar panel makers such as Panasonic, spurring them to manufacture even more energy-efficient products and services.

We also applaud the Singapore government for introducing the Energy Conservation Act, which comes into effect in 2013, to improve energy efficiency across different sectors. It will also drive energy efficiency in business. The legislation requires factories that consume more than 15GWh of energy a year to implement minimum energy management standards, such as the appointment of an energy manager, reporting of energy use and submission of energy efficiency improvement plans.

This is likely to help households make more informed choices about purchasing energy-efficient appliances since the legislation stipulates the minimum energy performance standards and energy labelling scheme for common household appliances such as air-conditioners and refrigerators.

Yorihisa Shiokawa is Managing Executive Officer, Regional Head for the Asia Pacific, Middle East & Africa of Panasonic Corporation, as well as Managing Director of Panasonic Asia Pacific. He assumed his role from April 2011, after three decades of building the brand name Panasonic in markets such as Europe, notably its digital audio-visual product and home appliance businesses.

This article was originally published on the Singapore International Energy Week 2012 website, and has been republished with permission.

Source: http://www.eco-business.com/features/5qs-with-panasonics-yorihisa-shiokawa/

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Old Fashioned Burger Stand To Re-open in Sacramento Commercial

Regional Vice President, Brian Jacks, is featured today on the front page of the Sacramento Press:

?Empty restaurant buildings continue to sit idle throughout much of the greater Sacramento area. Not so for the old Jolly Burger located at 7150 Auburn Blvd in Citrus Heights. A new operator will open the local burger stand with the same name on Friday, September 28, 2012.? Click Here to continue reading.

Article contributed by Brian Jacks

Brian Jacks?is a?Sacramento commercial real estate broker?(since 1996) specializing in commercial leasing and investment sale transactions for retail, shopping centers, multifamily, apartments, senior housing, office, industrial, mixed-use, and special purpose properties.? Having spent over 20 years with Wells Fargo, he personally facilitated the underwriting, approval and funding of almost 250 loans totaling over $1 billion in loan proceeds.

Jacks is a Regional Vice President for EAST WEST Commercial Real Estate, a full service commercial real estate brokerage advisor based in Orange County. ?In addition to serving the Sacramento marketplace, he is also responsible for the company?s current expansion into the San Francisco Bay Area. ?For more information, contact:

Brian.Jacks@EastWestCommercial.com
Cell (916) 837-3456 | eFax (916) 313-3778
915 L Street, Suite C440,?Sacramento, CA 95814

Broker Lic. #01217349

About EAST WEST Commercial Real Estate

EAST WEST Commercial Real Estate?is a full service?commercial real estate brokerage?advisor specializing in investment sales, commercial leasing and finance for retail, office, industrial multifamily, senior housing, self-storage, mixed-use and special purpose properties throughout California and Arizona.? The firm is headquartered in Orange County, CA.? Brokerage offices include Sacramento, San Francisco, Walnut Creek, San Jose, Oakland, Los Angeles, San Diego, Orange County, Riverside, San Bernardino and Phoenix.? Other services include bank REOs, 1031 exchanges, nationwide commercial Business Opinions of Value (BOV?s) and Broker Price Opinions (BPO?s), mortgage brokerage, lender services, and asset management.

Source: http://www.eastwestcommercial.com/2012/09/25/old-fashioned-burger-stand-to-re-open-in-sacramento-commercial-property-on-auburn-blvd-in-citrus-heights.html

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Video: About.com 'Hot Potato' We Wanted: IAC CEO

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Source: http://video.msnbc.msn.com/cnbc/49161627/

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Orioles split with Jays, stand 1 1/2 back

By DAVID GINSBURG

AP Sports Writer

Associated Press Sports

updated 11:01 p.m. ET Sept. 24, 2012

BALTIMORE (AP) - The Baltimore Orioles dreaded this doubleheader ever since it became part of their schedule late last month.

Beating the same team twice on the same day is not an easy task, even if the opposition is a last-place club in the midst of a losing streak. And so, after Toronto earned a split with a 9-5 win Monday night, the Orioles shrugged their shoulders and looked ahead to another day of chasing the New York Yankees in the AL East.

"Very hard to sweep a doubleheader in the major leagues," Baltimore manager Buck Showalter said. "It wasn't from a lack of effort. That's why when you get a rainout, you try to play because you know the challenge ahead of you somewhere down the line. The Blue Jays have a lot of pride."

J.P. Arencibia broke open a tight game with a seventh-inning grand slam, leaving the Orioles 1 1/2 games out of first place in the division.

In the opener, Adam Jones went 4 for 4 with a homer and two RBIs to lead Baltimore to a 4-1 victory. But the Orioles lost a half-game in the standings to the Yankees, who won 6-3 at Minnesota.

The doubleheader came into being after the teams endured a rainout on Aug. 26.

"You never want to play games like this late in the season," Baltimore right fielder Chris Davis said. "But at the same time, if you can win both of them, you help yourself out. Obviously we weren't able to do that."

The Orioles fell behind 4-0 in the nightcap and missed several bases-loaded chances to take the lead before Arencibia connected off Jake Arrieta to give Toronto a 9-4 cushion.

"I think anytime you strand guys on base you know it's a missed opportunity," Davis said.

Edwin Encarnacion hit his 41st home run for the Blue Jays, who snapped a seven-game skid. Arencibia, who came into the game mired in a 2-for-36 slump, finished with three hits and five RBIs.

Toronto long ago fell out of playoff contention, but the Jays were reminded how fun it is while performing before an enthusiastic crowd of 31,015.

"It's pretty impressive the atmosphere they have here," Arencibia said. "It's a lot of fun to play in that kind of atmosphere."

Ricky Romero (9-14) allowed four runs, eight hits, four walks and a homer in five-plus innings. But a strong performance by the Toronto bullpen enabled the left-hander to end a 13-game losing streak over 15 starts since June 22.

"Good for him and good for us," Blue Jays manager John Farrell said. "We needed a win and it's been a long time since Ricky's had a W."

Encarnacion put the Blue Jays up 2-0 against Wei-Yin Chen (12-10) with a two-run drive in the first inning. In the second, Arencibia hit a sacrifice fly and Anthony Gose added an RBI single.

Robert Andino singled in two runs in the bottom half, but Baltimore left the bases loaded. Nate McLouth hit an opposite-field drive to left in the fifth to get Baltimore to 4-3, but the Orioles again left the bases full.

After Moises Sierra homered for Toronto in the sixth, the Orioles loaded the bases with no outs in their half, bringing many in the crowd to their feet. Brad Lincoln replaced Romero and gave up a first-pitch RBI single to J.J. Hardy before striking out Jones. Davis followed with a fly ball to Gose in left field, and Taylor Teagarden was thrown out at the plate after tagging up.

Baltimore also loaded the bases with no outs in the ninth, but scored only once on a double-play grounder.

In the first game, Orioles rookie Steve Johnson (4-0) allowed three hits over five shutout innings to lower his ERA to 1.62. Half his big league wins have come against Toronto.

Although the Blue Jays got two runners on base in three of the first four innings, Johnson worked out of trouble on each occasion.

Jim Johnson, the fifth Baltimore pitcher, worked the ninth for his major league-best 48th save in 51 opportunities.

Jones' four hits tied a career high. Now in his seventh season, Jones has already set career highs with 32 homers and 101 runs, and the All-Star center fielder needs only three RBIs to eclipse his previous high of 83, set last year.

Jones added a single and a double in the nightcap and has hit safely in 19 of 23 games in September, with six home runs and 13 RBIs.

"Adam relishes competition," Showalter said. "He's obviously had a heck of a year. He's turning into quite a player."

Henderson Alvarez (9-14) gave up four runs, eight hits and three walks in 5 2-3 innings. He is 2-7 in his last 10 starts.

In the fourth, Davis walked and Jones followed with a drive to left to put Baltimore up 2-0. Ryan Flaherty hit a solo shot in the fifth, and Jones singled in the sixth and came home on a double-play grounder.

Toronto scored in the eighth on an RBI double by Rajai Davis. With runners on second and third and two outs, Darren O'Day came in to strike out Kelly Johnson.

NOTES: Toronto purchased the contracts of RHPs Shawn Hill and Bobby Korecky and transferred LHP J.A. Happ (foot) to the 60-day DL. ... Orioles LHP Randy Wolf is experiencing discomfort in his left elbow and will undergo an MRI on Tuesday. ... Seventeen of Jones' HRs have given the Orioles the lead. Baltimore is 23-8 when he homers. ... Toronto's first-game defeat was its sixth straight in Baltimore, its longest single-season skid in Charm City since 1980. The Orioles are 10-6 against the Blue Jays, clinching their first season series win over Toronto since 2004. ... Omar Vizquel got two hits to move into a tie with Mel Ott for 40th on the career list with 2,876.

? 2012 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

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Pettitte shines for Yanks again

Andy Pettitte turned in another ageless performance by pitching six scoreless innings and the New York Yankees hit four home runs Monday night to beat the Minnesota Twins 6-3 and extend their AL East lead.

Orioles split with Jays, stand 1 1/2 back

BALTIMORE (AP) - J.P. Arencibia broke open a tight game with a seventh-inning grand slam, and the Toronto Blue Jays beat Baltimore 9-5 Monday night to earn a doubleheader split and drop the Orioles 11/2 games out of first place in the AL East.

Source: http://nbcsports.msnbc.com/id/49157795/ns/sports-baseball/

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